A concise enantioselective total synthesis of (+)- epi-muricatacin, using asymmetric hydrogenation/intramolecular iodoetherification as key steps

Abstract

A concise enantioselective total synthesis of (+)- epi-muricatacin, a potent cytotoxic agent, is described. A key feature of this protocol is a catalytic asymmetric hydrogenation and a chiral auxiliary mediated intramolecular iodoetherification to ensure a high degree of distereo- and enantiocontrol.