Abstract
An efficient and general strategy to (R)-goniothalamin and (R)-goniothalamin oxide is described by using Jacobsen's hydrolytic kinetic resolution of racemic epoxide and ring-closing metathesis (RCM) as key steps, which provided a rapid access to these natural products that display a fascinating array of biological activity. (R)-Goniothalamin oxide was prepared in high yield and diastereomeric excess under various epoxidation conditions.
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