Year-end Sale % OFF 
Abstract
A series of 18-Ar-spirotryprostatin A analogs were synthesized stereoselectively from isatin via a five-step reaction sequence involving Wittig reaction, 1,3-dipolar cycloaddition, amidated ring closure reaction, hydrolyze and decarboxylation. The two one-pot reactions employed in the synthetic route resulted in high yields. The 1,3-dipolar cycloaddition reaction exhibited a diastereomeric ratio (dr) exceeding 20:1 and an enantiomeric ratio (er) reaching 90:10. Additionally, the amidated ring closure reaction achieved yields of up to 93%.
Published Version
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
