A concise and simple click reaction catalyzed by immobilized Cu(I) in an ionic liquid leading to the synthesis of β-hydroxy triazoles

Abstract

This study describes an ecocompatible, concise, and practically reliable approach for the regioselective synthesis of β-hydroxy triazoles via Huisgen's click coupling reaction among varied epoxides, NaN 3 , and suitable acetylenes catalysed by immobilized Cu(I) in ionic liquid (IL). This one-pot, atom-economic, efficient, and highly regioselective green protocol ensures higher yield of β-hydroxy triazole scaffolds (85–95%). To make the process ecofriendly, this study emphasizes on the catalyst immobilization technique along with its possible recycling that gave a high reaction yield in up to three runs. The structures of all synthesized compounds have been characterized by comparing 1 H nuclear magnetic resonance (NMR), 13 C NMR, and mass spectroscopic data with those reported in the literature.