Abstract
Deviations from chemical parity (PV) were evaluated with the search for very small enantiomeric excesses in a racemate prepared from non chiral materials and were detected by means of the circular dichroism (CD). Thus, intensely light-absorbing perylenebiscarboximides were attached to axially chiral biphenyls for the amplification of CD effects by exciton interactions of the adjacent chromophores. A rapidly racemising system was applied for the exclusion of artifacts and compared with an analogous with locked chirally. A very slight enantiomeric excess was detected for the (M) enantiomer. Application of the method for other systems was suggested and relations to natural products discussed.
Highlights
Nature handles chemical substances and processes remarkably sustainable where the chirality of natural products is dominant contrasting the majority of synthetic technical materials
Deviations from chemical parity (PV) were evaluated with the search for very small enantiomeric excesses in a racemate prepared from non chiral materials and were detected by means of the circular dichroism (CD)
Very strong CD effects were induced by exciton interactions of adjacent chromophores in chiral arrangements in dyads so that the required high signal amplifications are obtained
Summary
How to cite this paper: Langhals, H. and Krotz, O. (2018) A Concept for a Novel Test for Chemical Parity. How to cite this paper: Langhals, H. and Krotz, O. (2018) A Concept for a Novel Test for Chemical Parity. Received: August 17, 2018 Accepted: October 26, 2018 Published: October 29, 2018
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