Abstract
Flash NanoPrecipitation (FNP) is a novel approach for producing functional nanoparticles stabilized by amphiphilic block copolymers. FNP involves the rapid mixing of a hydrophobic active (organic) and an amphiphilic di-block copolymer with a non-solvent (water) and subsequent co-precipitation of nanoparticles composed of both the organic and copolymer. During this process, the particle size distribution (PSD) is frozen and stabilized by the hydrophilic portion of the amphiphilic di-block copolymer residing on the particle surface. That is, the particle growth is kinetically arrested and thus a narrow PSD can be attained. To model the co-precipitation process, a bivariate population balance equation (PBE) has been formulated to account for the competitive aggregation of the organic and copolymer versus pure organic-organic or copolymer-copolymer J. C. Cheng, R. D. Vigil, and R. O. Fox. A competitive aggregationmodel for flash nanoprecipitation. Journal of Colloid and Interface Science, 2010, doi:10.1016/j.jcis.2010.07.066. (48) Department of Chemical & Biological Engineering, Iowa State University, 2114 Sweeney Hall, Ames, Iowa 50011-2230, USA Primary researcher, author Model developer, instructor Author for correspondence
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