Abstract
An online computer system for the analysis of the molecular evolution modes of genes and proteins has been developed (SAMEM: http://pixie.bionet.nsc.ru/samem ). SAMEM computations are based on the ratio of radical to conservative amino acid substitutions (K R /K C ), the rate of amino acid substitutions in the course of protein evolution (V P ), and statistical relationships between the evolutionary changes of all known amino acid properties and particular features of an organism. The system facilitates the interpretation of the results of K R /K C and V P analyses.
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