Abstract
The model of the sarcoplasmic reticulum (SR) calcium release mechanism is based on reported experimental data of Ca++ cycling that include kinetics of Ca++ release, interaction with Ca++ buffers in the myoplasm, and Ca++ uptake. The model accounts for the SR channels that affect the regulation of Ca++ release. The SR channel regulating mechanism includes positive and negative feedback loops associated in the model with two types of Ca++ binding sites: 1) low affinity sites with high binding rates, representing the activation process that enhance Ca++ release from the channel ana 2) high affinity sites with low binding rates, representing the inactivation process. Ca++ release regulation by SR channels gives a satisfactory description of the mechanical restitution behavior.
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