Abstract
Neurotransmission is highly sensitive to the pH of the extracellular milieu. This is readily evident in the neurological symptoms that accompany systemic acid/base imbalances. Imaging data from sensory ribbon-type synapses show that neurotransmission itself can acidify the synaptic cleft, likely due to the co-release of protons, glutamate and ATP. It is not clear if the pH changes within the cleft of conventional neuronal synapses, but if it does it would provide for an additional layer of activity-dependent modulation of neurotransmission.
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