Abstract
A mathematical model of the intraerythrocytic developmental cycle identifies a delay between subtelomeric and central chromosomal gene activities in the malaria parasite, Plasmodium falciparum.
Highlights
The malaria parasite, Plasmodium falciparum, replicates asexually in a well-defined infection cycle within human erythrocytes
To model the infection cycle and obtain the rate of change for each gene at any time, we built a mathematical model of the intra-erythrocytic developmental cycle (IDC) by using a non-linear dimensionality reduction technique based on neural networks, termed circular principal component analysis (PCA) [3]
To model the infection cycle of the P. falciparum parasite during its intra-erythrocytic development, we built a mathematical model of the IDC
Summary
The malaria parasite, Plasmodium falciparum, replicates asexually in a well-defined infection cycle within human erythrocytes (red blood cells). The life cycle of Plasmodium includes multiple stages of development that take place in the mosquito vector and, upon infection of humans, in liver and red blood cells (RBCs). Bozdech et al [1] and Llinas et al [2] presented highly time-resolved microarray analyses of the transcriptomes of P. falciparum strains HB3, 3D7, and Dd2 during their IDC. In these analyses most genes were shown to behave in a sinusoidal fashion, with one peak of strong upregulation and one dip in the expression data.
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