Abstract
The polyherbalism that is a combination of two or more herbs expresses the fundamental aspect of Ayurvedic/herbal drug formulation. As per the many pieces of evidence shows the various herbal formulation with different potency acts by a unique mechanism. By which the Polyherbal formulation today make the choice for threatened disease or disorder rather than single one, to gain synergistic therapeutic application. The allergens produce immunoglobulin E (IgE)-mediated immune response and instant hypersensitivity reaction result in asthma, hay fever, atopic dermatitis, allergic rhinitis, food, and drug-induced allergies. Taking into consideration the etiology of upper respiratory tract infection, nowadays antihistamines are the choice of drug for the treatment of viral infections of the upper respiratory tract can be practice to stop complex inflammatory mediated reaction mainly effective in adult patients. The different plant species are discovered and applied over various clinical manifestations related to an allergic response. According to the traditional system of medicine, common plant species with their plant part used in some Antihistaminic Polyherbal formulation were assessed by Animal model work on the allergic response which includes HK-07, Unani eye drop, Bharangyadi, Ashmi, Pentapala-04. This study proved that many herbs combination has anti-histaminic and anti-allergic activity.
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