Abstract
Lipid-based drug delivery systems are extensively reported in the literature for enhancing drug solubility, permeability, and bioavailability. Self-nanoemulsifying drug delivery systems (SNEDDS) are a superior strategy for enhancing solubility and bioavailability of poorly water-soluble compounds and the most prevailing and commercially viable oil-based approach for drugs that exhibit low dissolution rate and inadequate absorption. However, these formulations have few limitations that include in vivo drug precipitation, inferior in vitro in vivo correlation owing to unavailability of in vitro tests, handling issues of liquid formulation, and physicochemical instability of drugs. These limitations are overcome by potential systems such as supersaturable SNEDDS (S-SNEDDS) which are prepared by addition of precipitation inhibitors into formulated SNEDDS to maintain drug supersaturation post dispersion in gastrointestinal tract. These systems improve drug bioavailability and reduce the inconsistency of exposure. In addition, these formulations also help to overcome the drawbacks of liquid and capsule dosage forms. The S-SNEDDS provides an effective approach for improving the dissolution and bioavailability of anti-cancer agents. In this article, an attempt was made to present an overview of SNEDDS, S-SNEDDS, their mechanism, formulation excipients, recent advancements, advantages, and disadvantages of SNEDDS formulations. The article also focuses on reviewing the application of S-SNEDDS in enhancing the solubility and bioavailability of anti-cancer drugs in cancer therapy.
Highlights
Oral route for drug delivery represents more than 70% of total dosage forms utilized by humans, and this can be related to its convenient and acceptability as a mean for the administration of drug molecules to patients since it associates with a high rate of patient compliance in one hand and economic and flexible dosage design in others [1,2]
One of the most important prerequisite requirements of drug molecules to be available for systemic absorption is aqueous solubility since that is the nature of GIT fluid
Selfnanoemulsifying drug delivery systems (SNEDDS) approach is applied for Biopharmaceutical Classification System (BCS) Class II drugs that suffer from inferior water solubility and bioavailability [22]
Summary
Oral route for drug delivery represents more than 70% of total dosage forms utilized by humans, and this can be related to its convenient and acceptability as a mean for the administration of drug molecules to patients since it associates with a high rate of patient compliance in one hand and economic and flexible dosage design in others [1,2]. SNEDDS approach is applied for BCS Class II drugs that suffer from inferior water solubility and bioavailability [22]. Oils The oil is used in SNEDDS formulation for solubilizing the lipophilic drug and ease self-emulsification, to augment the amount of drug passing through the intestinal lymphatic system, enhancing absorption. Drugs that are highly soluble in surfactants or cosurfactant than lipophilic phase precipitate as the solvent ability of these excipients reduces with dilution.
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