Abstract
Abstract: Atopic dermatitis is a chronic inflammatory disease that causes eczema, rashes, and itching. It is most common in younger people & adolescence. Recurrent relapses are a characteristic feature of atopic eczema. Anti-inflammatory therapy of exacerbations is aimed to control effectively disease activity and permit a return to basic dermatological therapy as soon as possible. Oxidative stress & inflammatory responses are thought to be responsible for the pathogenesis of atopic dermatitis. Silymarin is a polyphenolic flavonoid derived from the seed of milk thistle (Silybum marianum (L.) Gaertner) that has antiinflammatory, antioxidant and cytoprotective effect. Silymarin is a naturally occurring flavonoid medication, and recent studies have shown that it may be used to treat atopic dermatitis (AD). The primary goal of this effort is to formulate silymarin into a pluronic-lecithin organogel (PLO) base for topical skin administration. Utilizing two cosolvent systems of ethyl alcohol and dimethyl sulfoxide, six distinct PLO formulations with varied pluronic to lecithin ratios were created.
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