Abstract
Oral drug delivery system of Mouth Dissolving Tablets (MDTs) is using a new concept that have been mostly accepted in the pharmaceutical industry in recent days. This system is the most comfortable, safest and inexpensive of drug delivery system, enhancing the patient compliance and extending the patient life. Mouth dissolving formulations using an important ingredient or active agent due to allow release of drug is rapidly after that produce faster dissolution process. The mouth dissolving tablets contain a unique property of tablets like quickly disintegrating or easily dissolving and releasing the active drug within a few minutes and its contact with saliva. In pediatric, geriatric, bed ridden, psychic, dysphagic patients are using the MDTs because of these tablets are easily engulfing or swallowing is most convenient and patient compliance is better to compared than other Delivery systems. The tablets are formulated with an aid of super disintegrant. It's more reliable because of better compliance in patients. There are several technologies used in the MDTs manufacturing process such as patented technology & conventional technology. The important patented technologies are Durasolve Technology, Orasolve Technology, Zydis Technology, Wow Tab Technology, Flash Dose Technology, Flash Tab Technology and Quick Solv Technology. The MDTs are improving the demand for rapidly growing areas in the pharmaceutical industry and other fields are also in demand on these formulations. The recent progress of pharmaceutical fields is allowing the improvement of a better route of health care management with avoidance of numerous difficulties are connected to the other Drug Delivery System (DDS).
Highlights
According to EP: These Mouth Dissolving Tablets (MDTs) should dissolve/disintegrate very quickly in the mouth without the need of water.According to USFDA: Defined as solid dosage from containing medicinal substances or active ingredients which disintegrates rapidly within a few seconds when placed up on tongue [1].The MDTs have preferred to alternative conventional dosage form such as tablets, capsules and liquid pharmaceutical preparation
There are using several synonyms terms are used in the MDTs like Quick dissolving tablets, Fast melt tablets, orally disintegrating agent, Rapid disintegrating tablets, Oro disperse tablets, Freeze dried wafers
MDTs didn't require for water because of the tablet are quickly break down and disintegrate in saliva and dissolution can occur under the tongue or in buccal cavity
Summary
According to EP: These MDTs should dissolve/disintegrate very quickly in the mouth without the need of water.According to USFDA: Defined as solid dosage from containing medicinal substances or active ingredients which disintegrates rapidly within a few seconds when placed up on tongue [1].The MDTs have preferred to alternative conventional dosage form such as tablets, capsules and liquid pharmaceutical preparation. According to EP: These MDTs should dissolve/disintegrate very quickly in the mouth without the need of water. Some of the MDTs are may rapidly break into a small interval and rapidly goes into systemic absorption. Another few tablets contains a DI agent to increase the Disintegration (DI) of tablets. MDTs are intended to disintegrate rapidly and dissolve in the mouth less than 60 seconds or short span 20-30 seconds and its produce rapid on action for previous to ingestion, the active pharmaceutical ingredient (API) is designed to be delivered or retained in the gastrointestinal tract [4,5,6]. To ensure that the patient receives an appropriate dose of medication in a timely way, and using these disintegrating agents including sweeteners and flavors mask the taste for bitter taste
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