A comprehensive review on liposomes: A vesicular system for drug delivery

Vijay Kumar Vijay Kumar,Ikram Ikram,Aparna Joshi Aparna Joshi,Kapil Kumar Kapil Kumar,Deepak Teotia Deepak Teotia

doi:10.30574/gscbps.2022.18.2.0084

Abstract

In the last few years, many techniques have been utilized to enhance the pharmacological activity of any Active Pharmaceutical Drug [API] resulting in better bioavailability and lesser side effects. Liposomal drug delivery has evolved in this manner to increase the drug effect and reduce side effects. This review article focuses on all the aspects of liposomes with formulation methodology and characterization. Liposomes seem the first choice for designing a drug delivery system.

Highlights

Many drugs experience very low bioavailability, poor pharmacokinetic profile, and high side effects which may be because of poor solubility of the drug or because of the physicochemical nature of the drug
Particle Size Determination Both particle size and particle size distribution of liposomes can be determined by using following methods;
Surface charges The method involved in the measurement of surface charge is based on free-flow electrophoresis of Multi-Layer Varistors (MLVs)

Summary

Introduction

Many drugs experience very low bioavailability, poor pharmacokinetic profile, and high side effects which may be because of poor solubility of the drug or because of the physicochemical nature of the drug. To get better results and boost the therapeutic efficacy of the narrow range drugs nanotechnology has shown significant outcomes. Liposomes are one of the parts of the Nano-system with notable outcomes [1-4]. Liposomes are colloidal vesicles made up of one or more lipid bilayers surrounded by aqueous compartments. Liposomes encapsulate different types of drugs like antibiotics, antifungal, anticancer, proteins, hormones, peptides etc. Many drugs achieve therapeutically level for very less time because of metabolism of drug Liposomes can act as a promising carrier to delivery of drugs and to archives therapeutics level [5]

Methods

Results

Conclusion