A Comprehensive Review on Cu‐Catalysed Aerobic Oxidation of Amines to Imines

Abstract

AbstractImines are frequently used as valuable intermediates in organic transformation and pharmaceutical synthesis. Conventional imine synthesis includes Lewis acid catalysts, dehydrating agents, and unstable aldehydes. Developing eco‐friendly molecular assembly techniques has become increasingly important in recent years. In particular, there is a significant need for methods that recycle resources and have high atomic efficiency with minimal environmental impact. Oxidative synthesis of imines from amines has been investigated in presence of molecular oxygen (or air) which is readily accessible on Earth. The closely linked catalysts have been classified into metals, bio‐inspired, and MOF catalysts. Highly active, affordable, and adaptable copper based catalysts are given special attention here, some critical elements that influence reaction processes and catalytic activity are also displayed in the present study. The modern methods along with mechanistic routes for converting primary amines to imines using copper catalytic systems and ambient oxygen have been discussed in detail.