Abstract
Abstract: SARS-Cov-2, the new coronavirus which caused COVID-19 was first detected in Wuhan, China in december 2019.The first case of COVID-19 infection in India was reported in Kerala on Jan 27, 2020. Later on this contagious disease had quickly spread around the world. This review article aims at providing an exhaustive knowledge about the COVID-19 outbreak, mutant strains of coronavirus, mutation in spike protein of the virus, efficiency of vaccines on variants of concerns. It’s important to study the epidemiology of each variants/strains [alpha (B.1.1.7), beta (B.1.351), delta(B.1.617.2), omicron(B.11.529)] in order to develop vaccines and to cure this malady. How symptoms of different variants/strain and the reaction of these variants to different types of vaccines is also discussed.
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