Abstract
The kinase-mediated phosphorylation impacts every basic cellular process. While mitogen-activated protein kinase technology kinase kinases (MAP4Ks) are evolutionarily conserved, there is no comprehensive overview of the MAP4K family in the green lineage (Viridiplantae). In this study, we identified putative MAP4K members from representative species of the two core groups in the green lineage: Chlorophyta, which is a diverse group of green algae, and Streptophyta, which is mostly freshwater green algae and land plants. From that, we inferred the evolutionary relationships of MAP4K proteins through a phylogenetic reconstruction. Furthermore, we provided a classification of the MAP4Ks in the green lineage into three distinct.
Highlights
Post-translational modifications (PTMs) are vital for plants to sense and respond to environmental changes (Hashiguchi and Komatsu, 2016; Vu et al, 2018)
The MAP4K Family Members in A. thaliana In A. thaliana, the MAP4K family consists of 10 members, namely, MAP4K1 (At1G53165), MAP4K2 (At3G15220), MAP4K3/SALT INDUCIBLE KINASE 1 (SIK1) (At1G69220), MAP4K4/TARGET OF TEMPERATURE 3 (TOT3) (At5G14720), MAP4K5/TOI5 (At4G24100), MAP4K6/TOT3-INTERACTING PROTEIN 4 (TOI4) (At4G10730), MAP4K7 (At1G70430), MAP4K8 (At1G79640), MAP4K9 (At1G23700), and MAP4K10/BLUE LIGHT SIGNALING 1 (BLUS1) (At4G14480) (Pan and De Smet, 2020; Vu et al, 2021)
In Homo sapiens, MAP4Ks contain a characteristic, highly conserved C-terminal citron-homology domain (CNH) in all seven known members of the group (Chuang et al, 2016; Seo et al, 2020), which is present in MAP4K orthologs in Drosophila melanogaster and Caenorhabditis elegans (Fiedler et al, 2014), which is important for protein–protein interactions (Poinat et al, 2002; Machida et al, 2004; Taira et al, 2004)
Summary
Lixia Pan1,2†, Cassio Flavio Fonseca De Lima1,2†, Lam Dai Vu1,2 and Ive De Smet1,2*. Edited by: Angelica Cibrian-Jaramillo, Centro de Investigaciones y Estudios Avanzados, Instituto Politécnico Nacional de México (CINVESTAV), Mexico. Reviewed by: Luis Delaye, Centro de Investigaciones y Estudios Avanzados, Instituto Politécnico. While mitogen-activated protein kinase technology kinase kinases (MAP4Ks) are evolutionarily conserved, there is no comprehensive overview of the MAP4K family in the green lineage (Viridiplantae). We identified putative MAP4K members from representative species of the two core groups in the green lineage: Chlorophyta, which is a diverse group of green algae, and Streptophyta, which is mostly freshwater green algae and land plants. We inferred the evolutionary relationships of MAP4K proteins through a phylogenetic reconstruction. We provided a classification of the MAP4Ks in the green lineage into three distinct
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