Abstract
The outbreak of COVID-19 has proven to be an unprecedented disaster for the whole world. The virus has inflicted billion of lives across the globe in all aspects—physically, psychologically, as well as socially. Compared to the previous strains of β-CoV genera- MERS and SARS, SARS-CoV-2 has significantly higher transmissibility and worst post-recovery implications. A frequent mutation in the initial SARS-CoV-2 strain has been a major cause of mortalities (approx. 3 million deaths) and uncontrolled virulence (approx. 1 billion positive cases). As far as clinical manifestations are concerned, this particular virus has exhibited deleterious impacts on systems other than the respiratory system (primary target organ), such as the brain, hematological system, liver, kidneys, endocrine system, etc. with no promising curatives to date. Lack of emergency treatments and shortage of life-saving drugs has promoted the repurposing of existing therapeutics along with the emergence of vaccines with the combined efforts of scientists and industrial experts in this short span. This review summarizes every detail on COVID-19 and emphasizes undermining the future approaches to minimize its prevalence to the remaining lives.
Highlights
The influence of viruses and viral infections on human history has been broadly described by the social history of viruses ever since the modifications in human behavior during the Neolithic period around 12,000 years ago (Baranowski et al, 2001; Fuchs et al, 2019)
This review summarizes every detail on COVID-19 and emphasizes undermining the future approaches to minimize its prevalence to the remaining lives
Variants of Interest (VOI): It can best be defined as an isolate of severe acute respiratory syndrome (SARS)-CoV-2 with genotypic and/or phenotypic changes compared to the reference genome
Summary
Reviewed by: Sandeep Kumar Shukla, Institute of Nuclear Medicine & Allied Sciences (DRDO), India. The virus has inflicted billion of lives across the globe in all aspects—physically, psychologically, as well as socially. Compared to the previous strains of b-CoV generaMERS and SARS, SARS-CoV-2 has significantly higher transmissibility and worst postrecovery implications. A frequent mutation in the initial SARS-CoV-2 strain has been a major cause of mortalities As far as clinical manifestations are concerned, this particular virus has exhibited deleterious impacts on systems other than the respiratory system (primary target organ), such as the brain, hematological system, liver, kidneys, endocrine system, etc. This review summarizes every detail on COVID-19 and emphasizes undermining the future approaches to minimize its prevalence to the remaining lives.
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