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Abstract
IntroductionParathyroid tumor, in particular carcinoma, is fairly rare among neoplasms of the endocrine system, unlike its benign counterpart. However, there is no bibliometric analysis in the field of parathyroid tumors comprehensively summarizing and discussing a large number of publications by a machine learning-based method.Materials and MethodsParathyroid tumor-related publications in PubMed from January 2001 to December 2020 were searched using the MeSH term “parathyroid neoplasms”. Latent Dirichlet allocation was adopted to identify the research topics from the abstract of each publication using Python.ResultsA total of 3,301 parathyroid tumor-associated publications were identified from the past 20 years, and included in further analyses. Research articles and case reports occupied the most proportion of publications, while the number of clinical studies and clinical trials decreased, especially in recent years. Technetium Tc 99m sestamibi was most studied among the diagnosis-related MeSH terms, while parathyroidectomy was among the treatment-related MeSH terms. The Latent Dirichlet allocation analyses showed that the top topics were 99mTc-MIBI imaging, parathyroidectomy, gene expression in the cluster of diagnosis research, treatment research, and basic research. Notably, scarce connections were shown between the basic research cluster and the other two clusters, indicating the requirements of translational study turning basic biological knowledge into clinical practice.ConclusionThe annual scientific publications on parathyroid tumors have scarcely changed during the last two decades. 99mTc-MIBI imaging, parathyroidectomy, and gene expression are the most concerned topics in parathyroid tumor research.
Highlights
Parathyroid tumor, in particular carcinoma, is fairly rare among neoplasms of the endocrine system, unlike its benign counterpart
The Parathyroid tumor (PT)-related meta-analysis was firstly shown in 2013, but without significant development, which may be caused by the decreasing number of clinical studies and trials
Fifteen countries published more than 100 records, with the USA as the top one (1144 publications), followed by Italy (583 publications), China (452 publications), FIGURE 3 | Country scientific production
Summary
Parathyroid tumor, in particular carcinoma, is fairly rare among neoplasms of the endocrine system, unlike its benign counterpart. There is no bibliometric analysis in the field of parathyroid tumors comprehensively summarizing and discussing a large number of publications by a machine learning-based method. Parathyroid tumor (PT), in particular carcinoma, is pretty rare among neoplasms of the endocrine system, unlike its benign counterpart (1). Unlike thyroid cancer, which shows a predominance in women, parathyroid carcinoma has a consistent incidence in both sexes (2). While most PTs are sporadic, various genetic diseases may cause PT, including hyperparathyroidism–jaw tumor syndrome and multiple endocrine neoplasias. Bibliometric analysis is often used to summarize the contributions of publications. There is no bibliometric analysis in the field of PT, comprehensively summarizing and discussing a large number of publications
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