Abstract
Pyroptosis is a lytic form of inflammatory cell death. Nonsynonymous single nucleotide polymorphisms (nsSNPs) have been accepted as biomarkers of disease susceptibility. In the present study nsSNPs of Gasdermin Superfamily Genes, presently proven to be involved in pyroptosis and consequently in the aetiology of many diseases, were screened for their functional and structural effects. 3 nsSNPs of GSDMA, 2 each of GSDMB, GSDMC and GSDMD, 6 nsSNPs of GSDME and 2 nsSNPs of DFNB59 gene were predicted to be deleterious; showing a decrease in structural stability by in-silico tools. Further in silico analysis of post-translationally modified Phosphorylation sites of members of gene family were checked for the presence of SNPs which may influence the PTM and consequently the protein function. The current study has comprehensively tried to analyse all Gasdermin family gene variants with different in-silico algorithms combined with already available literature of wet lab experiments, to propose a list of nsSNPs that are the potential targets for future functional genetic analysis.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callMore From: International Journal of Bioinformatics Research and Applications
Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
