A Comprehensive Analysis of Chinese, Japanese, Korean, US-PIMA Indian, and Trinidadian Screening Scores for Diabetes Risk Assessment and Prediction

Abstract

Risk assessment and developing predictive models for diabetes prevention is considered an important task. Therefore, we proposed to analyze and provide a comprehensive analysis of the performance of diabetes screening scores for risk assessment and prediction in five populations: the Chinese, Japanese, Korean, US-PIMA Indian, and Trinidadian populations, utilizing statistical and machine learning (ML) methods. Additionally, due to the present COVID-19 epidemic, it is necessary to investigate how diabetes and COVID-19 are related to one another. Thus, by using a sample of the Korean population, the interrelationship between diabetes and COVID-19 was further investigated. The results revealed that by using a statistical method, the optimal cut points among Chinese, Japanese, Korean, US-PIMA Indian, and Trinidadian populations were 6.205 mmol/L (FPG), 5.523 mmol/L (FPG), and 5.375% (HbA1c), 150.50–106.50 mg/dL (FBS), 123.50 mg/dL (2hPG), and 107.50 mg/dL (FBG), respectively, with AUC scores of 0.97, 0.80, 0.78, 0.85, 0.79, and 0.905. The results also confirmed that diabetes has a significant relationship with COVID-19 in the Korean population (p-value 0.001), with an adjusted OR of 1.21. Finally, the overall best ML models were performed by Naïve Bayes with AUC scores of 0.736, 0.75, and 0.83 in the Japanese, Korean, and Trinidadian populations, respectively.