Abstract
A magnetic targeting nanoparticle based on graphene oxide-ferroferric oxide (GO-Fe₃O₄) was investigated as a potential drug delivery vehicle. The formation of GO/Fe₃O₄ hybrid material was confirmed by Fourier transform infrared spectroscopy, X-ray diffraction, scanning electron microscopy and transmission electron microscopy. The GO/Fe₃O₄ hybrid still shows a higher saturation magnetization of 58.42 emu/g after coating with graphene oxide. Drug loading and releasing experiments demonstrate the GO-Fe₃O₄ hybrid has a good loading capacity of (6.47±0.08) mg/mg for temozolomide and a satisfactory release under slightly acidic condition. The MTT assays of glioma C6 cells exhibits the GO-Fe₃O₄ hybrid does not display toxicity with the concentration ranged from 40 to 120 μg/mL in vitro, while the complex of temozolomide loaded on GO/Fe₃O₄ has a better inhibitory effect on the proliferation of rat glioma C6 cells. All results suggest the prepared GO/Fe₃O₄ has potential applications in targeted anticancer drug delivery.
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