Abstract
Although we have shown in a previous paper (L. D'Ilario and M.M. Steffan, J. Mol. Catal., 47 (1988) 7) that the entrapment of enzyme molecules between cellulose membranes did not cause variations in the working of the biocatalyst, the total efficiency of the composite membrane bioreactor was clearly dependent upon the membrane porosity through the increase of the ‘apparent’ Michaelis-Menten constant, compared with that of the free enzyme in solution. In the present paper an attempt is made to work out a theoretical model of the bioreactor which, based on the diffusional characteristics of the system and of the kinetic properties of the enzyme, would allow prediction of the efficiency of the system. A model is proposed, based on the thermodynamics of the irreversible processes. The experimental data on the biotransformation carried out in our ‘composite membrane’ reactor are compared with the theoretical ones suggested in the present paper.
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