Abstract
A composite element (CE) bit design for magnetically encoded microcarriers provides an increased coercivity range for longer bit codes as well as significant improvements to encoding density, reliability and read-out.
Highlights
Combinatorial chemistry provides signi cant scaling advantages and has formed a cornerstone of medicinal chemistry over two decades ago
We present the composite element (CE) bit design and the intricacies that govern its encoding properties in order to demonstrate the reliability of the new barcode design
The hysteresis loops were measured by longitudinal magneto-optic Kerr effect[30] (MOKE) on elements with appropriate pitch using a NanoMOKE magnetometer, produced by Durham Magneto Optics Ltd., capable of focusing the laser down to a 5 mm spot diameter
Summary
Combinatorial chemistry provides signi cant scaling advantages and has formed a cornerstone of medicinal chemistry over two decades ago. With modern economies of scale favouring automation and especially with the rise of micro uidic technologies this efficiency trend has since progressed exponentially.[4,5] Here, we present advances in magnetic barcode design that make the use of suspended and magnetically encoded microcarriers (or tags) highly relevant for the development of future library generation and screening applications using lab-on-a-chip based combinatorial chemistry. The CE bits consist of multiple strips with high aspect ratios and are engineered to enable a signi cantly wider coercivity distribution while maintaining sharp magnetisation reversal behaviour for reliable encoding This makes the CE bit design highly relevant for the development of future micro uidics-based combinatorial chemistry applications, where each bit within a microcarrier can be individually encoded (when written from highest to lowest coercivity value) a er each split-and-mix process. We present the CE bit design and the intricacies that govern its encoding properties in order to demonstrate the reliability of the new barcode design
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