Abstract
Pseudomonas aeruginosa PAO1 was found to catabolise β-alanine and β-amino-iso-butyrate (β-AIB) by the following pathway: (i) transamination by β-alanine: pyruvate aminotransferase (BAPAT) to yield l-alanine and either malonic semialdehyde or its methyl analogue, respectively; (ii) oxidative decarboxylation of the respective semialdehydes to acetyl CoA or propionyl CoA; (iii) regeneration of pyruvate from l-alanine by the action of dl-alanine racemase (AR) and d-alanine dehydrogenase (DAD). Mutants defective in BAPAT or DAD failed to catabolise either β-alanine or β-AIB, and β-alanine was an inducer for the entire pathway.
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