Abstract
Malaria is a vector-borne disease causing extensive morbidity, debility and mortality. Development of resistance to drugs among parasites and to conventional insecticides among vector-mosquitoes necessitates innovative measures to combat this disease. Identification of molecules involved in the maintenance of complex developmental cycles of the parasites within the vector and the host can provide attractive targets to intervene in the disease transmission. In the last decade, several efforts have been made in identifying such molecules involved in mosquito-parasite interactions and, subsequently, validating their role in the development of parasites within the vector. In this study, a list of mosquito proteins, which facilitate or inhibit the development of malaria parasites in the midgut, haemolymph and salivary glands of mosquitoes, is compiled. A total of 94 molecules have been reported and validated for their role in the development of malaria parasites inside the vector. This compendium of molecules will serve as a centralized resource to biomedical researchers investigating vector-pathogen interactions and malaria transmission.
Highlights
Malaria continues to be one of the most debilitating mosquito-borne diseases
A total of 41 different species of Anopheles mosquitoes act as vectors for transmission of human malaria [1]
There has been a considerable increase in the use of this technique in the recent years (Figure 2) and many mosquito proteins, which have a role in growth and survival of malaria parasites inside the Number of publications
Summary
Malaria continues to be one of the most debilitating mosquito-borne diseases. According to the WHO World Malaria Report in 2011, 216 million cases of malaria were reported in the year 2010, resulting in 655,000 deaths, of which 86% were children below five years of age. One of the approaches adopted towards limiting the spread of disease is to control the vector population by the reduction of breeding sites and use of insecticides and by minimizing mosquito-human contacts through In their complex life cycle, during sporogonic development malaria parasites are in intimate contact with midgut, haemolymph and salivary glands of vector mosquito. There has been a considerable increase in the use of this technique in the recent years (Figure 2) and many mosquito proteins, which have a role in growth and survival of malaria parasites inside the Number of publications. A literature survey was performed to gather and catalog mosquito proteins with an established role in parasite development Such a resource will be helpful in future investigations on candidate targets for strategies aimed at preventing malaria transmission
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