Abstract
The metabolism of several foreign compounds has been investigated in viable isolated liver and intestinal mucosal cells. Glucuronic acid and sulphate conjugation was observed in both cell preparations with respect to phenol. Conjugation of 1-naphthol was also observed in isolated intestinal cells. Acetanilide was the only metabolic product of aniline observed with intestinal cells. N-Acetylation was also found to be the major pathway of aniline metabolism in liver cells but p-hydroxylation followed by O-conjugation were also important reactions. Intestinal cells thus appear to be generally effective in conjugation reactions. However, in contrast to hepatocytes the intestinal cells were unable to form glycine conjugates from benzoic acid. The metabolism of 7-ethoxycoumarin and 7-hydroxycoumarin was investigated in isolated intestinal cells from control, 3-methylcholanthrene and phenobarbitone pretreated rats. Glucuronic acid and sulphate conjugation rates of 7-hydroxycoumarin appeared to be unaffected by these pretreatments whereas increases in 7-ethoxycoumarin O-deethylation were observed.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
