Abstract
A controller-independent controllability measure, the partial disturbance gain (PDG), is used for evaluating a continuous bioreactor’s sensitivity to disturbances. Five control schemes for continuous bioreactors are examined based on controllability analysis with respect to disturbance rejection. At substrate-limited growth conditions, the turbidostat using the feed substrate concentration as manipulated variable is the best control scheme. The conventional turbidostat should be avoided to use. When the cell growth is not substrate limited, all these control schemes are effective except the nutristat using feed substrate concentration as manipulated variable which is not feasible no matter whether the growth is substrate limited or not.
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