Abstract
The objective function is a key component of IMRT that is used to model the clinical goals. Most objective functions are based on dose and dose-volume considerations, although biologically-based functions have also been investigated. In this work we compare the plans for lung patients derived by optimizing using three different objective functions based on: a) dose-volume constraints b) a biological function based on a parallel architecture model for radiation pneumonitis c) mean lung dose. The quality of each objective function is measured by its ability to minimize each of the following four predictors for pneumonitis: a) volume of lung receiving 20Gy (V20), b) mean dose, c) parallel model parameter (fdam), and d) Lyman-Kutcher model of normal tissue complication probability (NTCP).
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