Abstract
Abstract A comparison was made of the response of the KHT sarcoma, transplanted into the thighs of syngeneic C3H mice, and the response of the normal tissues of the irradiated leg to two fractionation regimes; six fractions in two weeks and ten fractions in two weeks. The response of the tumour, which was measured by the delay in growth to a fixed size, was found to be consistent with a fractional difference between the two regimes of approximately 11 per cent for dose fractions of between 200 and 600 rads. For the normal tissues, early skin reactions and deformity 48 weeks after irradiation were measured, and the mean fractional difference between the two regimes was 12 per cent for the early and 13 per cent for the late reaction. The values of the “fraction number” exponent in the nominal standard dose equation of Ellis were calculated for both the tumour and normal tissues and found to be consistent with the value of 0·24.
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