Abstract
Sea nettle ( Chrysaora quinquecirrha) nematocyst venoms from the fishing and mesenteric tentacles were studied. Fishing tentacle nematocyst venom was more potent than mesenteric tentacle nematocyst venom in producing human cutaneous pain, mouse lethality, hemolysis, dermonecrosis, vasopermeability and damage to rat liver mitochondria. Both types of venom had similar enzyme contents except that mesenteric tentacle venom contained no hyaluronidase. The mouse lethal factors of both venoms had a molecular weight probably over 100,000, were not precipitated by 20% (NH 4) 2SO 4 and could be further fractionated by gel electrophoresis and isoelectric focusing.
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