Abstract
Paris Pasteur strain of rabies virus was adapted to multiplication in human diploid cell strains. Four lots of purified tissue culture vaccine prepared with this virus were compared with two similar vaccine lots prepared with the Pitman-Moore strain of rabies virus. According to the NIH test for potency, the vaccine prepared with the Pitman-Moore virus was about eight times more potent than the vaccine prepared with the Paris Pasteur strain of rabies virus. Both vaccines, however, elicited similar antibody responses in volunteers after four vaccine doses. Although the NIH test for potency may not represent a good parallel for immunogenicity of tissue culture rabies vaccine in man, the use of Pitman-Moore strain of virus seems preferable for the preparation of rabies vaccine in cultures of human diploid cells.
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