Abstract
Atopic and nonatopic subjects were exposed intranasally to a protein antigen, and observations were made on the development of skin reactivity of the immediate type, the occurrence of symptoms, and the appearance of skin-sensitizing capacity in the serum. These were induced exclusively or with greater frequency in the atopic group, and this was not attributable to antigen administered in the course of skin testing. Four among 10 nonatopic individuals developed delayed-type skin reactivity which was not observed among the atopic subjects. The ABO blood group secretor status was observed with equal frequency in allergic and nonallergic individuals and was unrelated to appearance of skin reactivity. It is suggested that atopic individuals differ from nonatopic in having a greater mucosal permeability to inhaled antigens.
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