Abstract
With the aim of investigating the pathogenesis of Duchenne dystrophy, and in particular the role of denervation, the fine structural features of motor end-plates in the limb muscles of 13 patients with Duchenne dystrophy were compared with those in 26 controls and 50 patients suffering from known neurogenic diseases. The wide variation in control end-plates is emphasised. The sole plates in Duchenne dystrophy tended to retract from the end-plate terminals, and shared only sprout formation, enclosure of terminals in Schwann cell cytoplasm and (in one instance) close packing of neurofilaments in the terminal with the changes in denervating end-plates. In these latter, withdrawal of terminals from the sole and various degenerative figures were the rule. It was concluded that there is no adequate morphological evidence in motor end-plates to support the concept of Duchenne dystrophy as a neurogenic disease.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
