Abstract
A study was made of the actions of microelectrophoretically administered 5-HT, NA and DA on the spontaneous and amino acid-induced firing of bulbar reticular neurones in unanaesthetized, decerebrate cats. Some of these neurones were activated antidromically and/or synaptically by stimulation of the cervical spinal cord and sciatic nerve. 5-HT and NA excited approximately one-third, depressed one-quarter and had a dual action on a few of the neurones tested. DA affected about half the cells, causing mainly depression, although it excited some neurones. Almost all reticulospinal neurones were excited by 5-HT and NA, but usually depressed or unaffected by DA. The depressant actions of the monoamines were generally rapid in onset and recovery, whereas the excitant actions were of a slow time course and sometimes showed desensitization on repeated applications. Various combinations of excitation and depression were observed when the effects of the monoamines were compared on the same neurone. Monoamine-sensitive cells seemed to be diffusely scattered throughout the bulbar reticular formation. The monoamines were usually less effective than glutamate and glycine.
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