Abstract
Summary A comparison of the effects of Mecholyl on esophageal intraluminal pressure in normal persons and in patients with cardiospasm has been made. Mecholyl produced a marked rise in intraluminal pressure in 11 of 15 patients with cardiospasm which was not observed in a control group of normal persons. The lack of a significant response to Mecholyl by 4 patients with cardiospasm may be related to the severity of their disease. Each had a markedly enlarged, dilated, atonic, and tortuous (decompensated) esophagus. Substernal distress, not observed in normal persons, occurred in two thirds of the patients with cardiospasm after the administration of Mecholyl. In general, these observations confirm the work of Kramer and Ingelfinger. The abnormally low deglutition pressure waves observed in patients with cardiospasm confirm the work of Butin and associates. Although low deglutition pressure waves were recorded for 1 patient, each having scleroderma, benign stricture, and diffuse spasm of the esophagus, none of the patients demonstrated hypersensitivity to Mecholyl. One patient with diffuse spasm of the esophagus had normal deglutition pressure waves.
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