Abstract
Background. Recurrent aphthous stomatitis (RAS) is one of the most common ulcerative diseases of the oral mucosa. Definitive etiology of RAS has not been conclusively established. There is no certain treatment for aphthous stomatitis but some drugs such as steroids are commonly used for the treatment of RAS. Regarding the effect of zinc on the healing process of epithelial layer and cell division, in this research the effect of triamcinolone (with orabase) in combination with a zinc-containing mouthwash and triamcinolone alone on the healing process of RAS lesions was assessed.Methods. The present study consisted of 20 patients diagnosed with RAS. The patients were instructed to rinse the mouth-wash or placebo three times a day and triamcinolone ointment twice a day for two weeks. The largest dimension of the ulcer was measured by a digital caliper and the severity of pain was assessed by visual analogue scale (VAS). Number, size, duration, ulcer-free period and pain of the lesions were evaluated twice a week for twomonths. Data were analyzed by SPSS 16 using Mann-Whitney U test and t-test.Results. A decrease was seen in the mean pain severity score (P = 0.631) and the size of the lesions but it was not statistically significant (P = 0.739). Also the difference between the number of lesions (P = 0.739), duration and ulcer-free period (P = 0.873) were not statistically significant.Conclusion. Zinc mouthwash seems to be as effective on wound healing process as typical treatment modalities for RAS.
Highlights
Recurrent aphthous stomatitis (RAS) is one of the most common oral diseases that affects up to 20% of the population.[1,2] The cause of RAS is unknown, several factors, including stress, genetics, allergy to certain foods such as milk, cheese and wheat, hematologic disorders, hormonal factors, nutritional deficiencies involving B12, folate, zinc, iron etc, are considered as predisposing factors.[1,2,3] The mucosal barrier appears to be an important factor in the prevention of aphthous stomatitis and might explain the almost exclusive location of aphthous stomatitis on nonkeratinized mucosa
There is no certain treatment for aphthous stomatitis but some drugs such as steroids are commonly used for the treatment of RAS
The largest dimension of the ulcer was measured by a digital caliper and the severity of pain was assessed by visual analogue scale (VAS)
Summary
Recurrent aphthous stomatitis (RAS) is one of the most common oral diseases that affects up to 20% of the population.[1,2] The cause of RAS is unknown, several factors, including stress, genetics, allergy to certain foods such as milk, cheese and wheat, hematologic disorders, hormonal factors, nutritional deficiencies involving B12, folate, zinc, iron etc, are considered as predisposing factors.[1,2,3] The mucosal barrier appears to be an important factor in the prevention of aphthous stomatitis and might explain the almost exclusive location of aphthous stomatitis on nonkeratinized mucosa. Tobacco use and lutheal phase of the menstrual cycle and pregnancy lead to increased keratinization of the oral mucosa and a decreased frequency of aphthous stomatitis.[2]. All the treatments are used to reduce pain, healing time, number and size of the lesions, and to prolong ulcer-free periods.[1]. Recurrent aphthous stomatitis (RAS) is one of the most common ulcerative diseases of the oral mucosa. Size, duration, ulcer-free period and pain of the lesions were evaluated twice a week for two months. The difference between the number of lesions (P = 0.739), duration and ulcer-free period (P = 0.873) were not statistically significant. Zinc mouthwash seems to be as effective on wound healing process as typical treatment modalities for RAS.
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