Abstract
SummaryA host‐versus‐graft reaction initiated by the intravenous injection of F1 (Balb/c × C57 Black) spleen cells into Balb/c mice is characterized by hepatosplenomegaly and a marked increase in the phagocytic activity of the reticuloendothelial system. Although the host‐versus‐graft reaction is accompanied by changes in reticuloendothelial organs which are also found in the graft‐versus‐host reaction, viz., phagocytic stimulation, splenomegaly and hepatomegaly, significant differences exist in the onset, duration and nature of the functional and morphological changes produced. They occur much earlier in the host‐versus‐graft reaction and persist for shorter periods. No increase in the relative number of liver macrophages occurs in the host‐versus‐graft reaction, and splenic enlargement is due to white pulp hyperplasia with prominent germinal centre development. In a situation where the potential exists for host‐versus‐graft and graft‐versus‐host reactions to occur simultaneously, such as that created by injecting CBA spleen cells into Balb/c mice, the host‐versus‐graft reaction develops and is of sufficient intensity to prevent the transplanted cells from mounting a graft‐versus‐host reaction against the recipient animal.
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