Abstract

THE inhibitory effect of progesterone on the estrogen-induced tissue growth response of the chick oviduct was reported by Hertz et al. (1947). Among other steroid hormones tested for inhibitory activity in the chick oviduct test, allopregnane-21-ol-3,20-dione acetate (cpd. I) proved to be a potent antagonist (Hertz, 1951). In a test for corticoid activity, Wettstein and Hunzicker (1940) reported the compound to be inactive for weight maintenance and survival in adrenalectomized rats at a daily dose of 2 mg. Since progesterone and cpd. I inhibit the estrogen-stimulated chick oviduct, further investigations were made to determine whether these compounds possessed any other common biological properties. In the present report, we present details of a comparison between progesterone and cpd. I based on certain biological actions exhibited by progesterone. MATERIALS AND METHODS (1) Oviduct inhibition test Two week old New Hampshire Red chicks were housed in electrically heated brooders under controlled lighting...

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