Abstract
On the basis of our previous studies concerning aminoarylthioalcenols, the selective transformation of the NH2 moiety into isothiocyanates is described. The scope and limitations of the thiourea synthesis was further investigated through the reaction of isothiocyanates with hydrazine hydrate. Depending on solvents used, the reaction did not afford thioureas but gave unexpected pyrazoles and hydrazones. The structures of all new products were established on the basis of their spectral data. For some of the new compounds, the antiviral activity was evaluated against an RNA-virus (poliovirus) and a DNA-virus (herpes simplex virus type 1). As only thiourea compounds showed any antiviral activity against both viruses, the thiourea moiety appeared to be crucial for this activity.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
