A comparison of spirometric variables in cystic fibrosis and bronchiectasis over 4 years

Abstract

Bronchiectasis, which is a sequel to childhood infection, is characterized by lung function decline akin to that in the general population (1,2). Bronchiectasis in cystic fibrosis is a consequence of altered mucus rheology, which predisposes the airway to mucoid impaction and recurrent lower respiratory infection. The pathology in cystic fibrosis is widespread and constantly active compared to bronchiectasis. This can cause a faster decline of lung function in cystic fibrosis. The goal of this report was to compare lung function decline in cystic fibrosis and bronchiectasis.