A comparison of simultaneous multislice and conventional diffusion tensor imaging techniques for ischemic stroke evaluation at 1.5T.

Abstract

Diffusion tensor imaging (DTI) is a promising technique for ischemic stroke evaluation; however, acquisition time is longer than DWI. Simultaneous multislice (SMS) imaging acquires multiple slices together and reduces scan time. This study compared conventional and SMS DTI for ischemic stroke workup. Following IRB approval, the departmental stroke protocol was supplemented with SMS DTI on a clinical 1.5T MRI. Cases suspicious for ischemic stroke outside the treatment window were included. Standard DTI (STD-DTI, 20-direction, b = 2000 s/mm2), was followed by SMS-2-DTI (two slices simultaneously imaged). Two blinded neuroradiologists independently assessed image quality and DTI-trace status (positive/negative = stroke/other). Average image quality, interrater reliability (κ), receiver operating characteristic area under the curve (AUC), signal-to-noise ratio (SNR = DTI-source min/max/average), coefficient of variation (CV), mean diffusivity (MD), and fractional anisotropy (FA, of DTI-trace) were compared using two-tailed t-tests and a p < .05. 41 patients were evaluated. SMS-2-DTI decreased DTI time by 132.17 ± 15.33 s, a 45% reduction. SMS-2-DTI reduced image quality (STD-DTI 4.7 ± 0.5 vs SMS-2-DTI 3.8 ± 0.6, p < .001). Diagnostic accuracy persisted, AUC was high for observer 1 (STD-DTI 0.95, 95%CI = 0.88-1.00 vs SMS-2-DTI 0.94, 95%CI = 0.87-1.00, p = .86) and observer 2 (STD-DTI 0.89, 95%CI = 0.79-0.99 vs SMS-2-DTI 0.86, 95%CI = 0.76-0.97, p = .66). Interrater reliability was high for STD-DTI (κ = 0.80, 95%CI = 0.61-0.98) and SMS-2-DTI (κ = 0.84, 95%CI = 0.67-1.00). SMS-2-DTI significantly decreased average SNR (STD-DTI 42.85 ± 4.44 vs SMS-2-DTI 32.58 ± 4.30, p < .001), and CV MD (STD-DTI 0.23 ± 0.03 vs 0.20 ± 0.04, p < .001). CV FA and CV DTI-trace were not statistically different. This study supports using SMS to accelerate DTI for ischemic stroke workup at 1.5T in the non-hyper-acute setting. This study highlights the feasibility of accelerated multislice DTI for faster diagnostic DTI-trace images capable of ischemic stroke detection.