Abstract
A comparison of retinol binding in human hyperplastic and malignant prostate
Highlights
There is evidence to suggest that vitamin A may mediate its biological actions through cellular retinol binding protein which binds the ligand and with high affinity (Ong & Chytil, 1975, 1978). cRBP may serve to deliver retinol from the cytoplasm to nuclear acceptor sites where it affects genetic read out (Liau et al, 1981)
The protein binds retinol with high affinity (35nM) and shows similar characteristics to the component analysed in other tissues (Bashor et al, 1973)
Reports from several laboratories suggest that the expression of cRBP in malignancy may be altered
Summary
There is evidence to suggest that vitamin A (retinol) may mediate its biological actions through cellular retinol binding protein (cRBP) which binds the ligand and with high affinity (Ong & Chytil, 1975, 1978). cRBP may serve to deliver retinol from the cytoplasm to nuclear acceptor sites where it affects genetic read out (Liau et al, 1981). The presence of cRBP in human (benign) hyperplastic prostate (BPH) has been reported by this laboratory (Boyd et al, 1984). In another study (Palan & Romney, 1980) reduced levels of cRBP were reported in a number of human tumours including lungs, ovaries and endometrium.
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
