A comparison of quantitative parameters of axial posture and spinal mobility between motor subtypes of Parkinson's disease.

Abstract

<p>Parkinson&rsquo;s disease (PD) is a heterogeneous neurodegenerative disorder characterized by contradictory clinical outcomes among its several subtypes. The disease can manifest with a tremor-dominant (TD) or a non-tremor-dominant (NTD) phenotype. Although the TD subtype may show a better prognosis, there is limited information on the phenotypic differences regarding the level of axial symptoms. For this reason, in this study it was aimed to make a quantitative comparison of axial posture and spinal mobility between PD with TD and NTD.&nbsp;</p>. <p>This case-control study was conducted on 94 patients with diagnosed PD. A group diagnosis approach was used in the study, such that the diagnosis of each patient was confirmed, and they were assig-ned to TD and NTD groups by a neurologist expert on movement disorders. Of the patients with PD, 61 were in the TD group, and 33 were in the NTD group. Spinal mouse was used to measure spinal posture and spinal mobility in both sagittal and frontal planes.&nbsp;</p>. <p>Two groups of 61 patients (25 male + 36 female) with TD-PD (mean age: 64.49&plusmn;10.37 years) and 33 patients (20 male +13 female) with NTD-PD (mean age: 63.45&plusmn;9.11 years) were enrolled in the study. There were no significant differences bet&shy;ween the patients with TD and NTD in terms of sagittal and frontal postures (p&gt;0.05). In addition to this, anterior trunk tilt was found to significantly increase as the disease stage advanced in both groups. While the greatest anterior trunk tilt change in the TD-PD group was observed in the 3rd stage, NTD-PD group was in the 2.5th stage. Aside from this, the out&shy;comes of the spinal mobility measurements in the frontal and sagittal planes were similar between the groups (p&gt;0.05).</p>. <p>It is widely acknowledged that many clinical aspects of the TD and NTD forms of PD differ; however, in our study, it was observed that there may be no difference in the axial symptoms of the patients with PD in terms of classification according to tremor dominance.</p>.