Abstract
BackgroundPyogenic liver abscess(PLA) has become common in patients with diabetes mellitus (DM), but it is unclear whether differences exist between patients with and without DM. A retrospective study was performed to identify these differences, summarize the clinical experience, and improve the diagnosis and treatment of PLA.MethodsThe patients were enrolled in a teaching hospital from January 2012 to December 2016. The patients were separated into two groups based on comorbidity with diabetes mellitus (DM). The DM group was further separated into two subgroups according to the HbA1C concentration to investigate whether glycaemic control affected the clinical characteristics of PLA patients with DM. Chi-square, Fisher’s exact test, and t-tests were used to analyse and evaluate differences between the two groups.ResultsTwo hundred and forty-six PLA patients were identified and 90 (36.6%) had comorbid DM. Patients with DM were older, had higher levels of alkaline phosphatase and γ-glutamyl transferase, hypertension, a loss of body weight, a single abscess, and combined antibiotic therapy with the use of carbapenems and Klebsiella pneumoniae in their blood cultures but a less frequent history of abdominal surgery and Escherichia coli in their pus cultures. When DM patients were compared to non-DM patients, each of these differences was significant (P < 0.05). Diabetic PLA patients with poor glycaemic control had a significantly higher proportion of fever and both lobes abscess(P < 0.05).ConclusionPLA patients with diabetes are older, have more serious complications, a higher prevalence of cardiovascular disease, an increased use of combined antibiotic therapy with carbapenem, and K. pneumoniae as the predominant pathogen, but these patients had fewer abdominal surgeries and fewer E. coli infections. In addition, poorly controlled glycaemia in diabetic PLA patients is associated with high incidence of fever and both lobes abscess.
Highlights
Pyogenic liver abscess(PLA) has become common in patients with diabetes mellitus (DM), but it is unclear whether differences exist between patients with and without DM
The criteria for type II DM were defined according to the 2017 standards [9]: 1)fasting plasma glucose (FPG) ≥ 126 mg/dL (7.0 mmol/L); 2)2-h plasma glucose (2-hPG) ≥ 200 mg/dL (11.1 mmol/L); 3) HbA1C ≥ 6.5% (48 mmol/mol); and 4) a random plasma glucose ≥200 mg/dL (11.1 mmol/L) in patients with classic symptoms of hyperglycaemia or hyperglycaemic crisis
246 patients were included in this retrospective study
Summary
Pyogenic liver abscess(PLA) has become common in patients with diabetes mellitus (DM), but it is unclear whether differences exist between patients with and without DM. Pyogenic liver abscess (PLA), which is a suppurating infection of the hepatic parenchyma, remains a condition associated with mortality and is reported in China and throughout the world, especially in Asia. The incidence rate of PLA is different worldwide and continues to increase annually [1]. In northeast China, an incidence of 5.7 cases per 100,000 individuals was reported in a large populationbased retrospective study [3]. In the United States, a large study described an incidence of 3.59 cases per 100,000 individuals [1]. PLA patients with concomitant DM have become more common in this hospital, and previous case reports
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