Abstract
Changes in respiration and glycolysis have been correlated with ion shifts in toad muscle. The effect of varying external levels of K +, Rb +, Cs + and Li + has been determined. High levels of K + increase the oxygen consumption of the tissue, and this effect passes through a maximum at approximately 18 mequiv./l K +. The lactic acid production of muscle was significantly increased at external K + levels of 40 mequiv./l or greater. Rb + resembled K + in its effect on respiration, but did not significantly alter lactic acid production. Cs + increased both respiration and glycolysis, but the effect did not show the peak response found with K + and Rb +. Li + caused an initial decrease in the rate of oxygen usage, and a later increase in this rate. These changes were associated with a decreased lactic acid production. It is suggested that the increase in oxygen consumption in high external levels of the alkali metal ions is associated with an uncoupling of oxidative phosphorylation. This is likely to be a surface effect, and may be related to the depolarisation of the membrane.
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