A comparison of in-Hospital complications with ST segment elevation resolution after thrombolytic therapy in acute myocardial infarction

Abstract

Background and objective: The primary goal of thrombolytic therapy in ST-segment elevation myocardial infarction is to restore the complete coronary reperfusion. The aim of the study was to assess the association of in- Hospital complications with ST-segment resolution after thrombolytic therapy in acute myocardial infarction. Methods:  The ECG s of 100 patients with first ST-segment elevation myocardial infarction were recorded on admission, 90 and 180 minutes after Alteplase at Hawler Teaching Hospital (Coronary Care Unit) from January 2011 to October 2011. The mean age (±SD)was 59.8±8.4years,ranging from 37-80 years, 63% were males and 37% were females, male to female ratio equal 1.7:1. Patients were divided into three groups: Group (A): complete resolution of ST segment, group (B) : partial resolution and group (C) no resolution of ST-segment, those patients were followed for the detection of in-Hospital complications. Results: Heart failure cardiogenic shock,left ventricular systolic dysfunction and ischemic mitral regurgitation were higher in group (B) and (C) than (A) when ECGs were recorded at 90 and 180 minutes after thrombolysis (P < 0.001). Conclusion: Failure or partial resolution of ST segment can predict the early development of heart failure, shock, left ventricular systolic dysfunction and ischemic mitral regurgitation.