Abstract
Purpose: To compare the number of hyper-reflective retinal spots (HRS) in optical coherence tomography (OCT) images of healthy controls and patients affected with primary open angle glaucoma (POAG). Methods: Thirty patients affected with POAG and 34 healthy controls were recruited and underwent raster OCT examination of the macular region. Among the acquired B-scans, the one with the lowest foveal thickness was selected, and a central area of 3000 μm was defined (region of interest, ROI), in order to identify HRS. HRS were defined as small point-like hyper-reflective elements, detectable at the visual inspection of the OCT image. HRS were independently counted by two investigators in the ROI of each OCT scan. Results: Inter-rater agreement for HRS counting was good to excellent (ICC = 0.96, 95% CI: 0.83–0.99). More HRS were found in the OCT images from glaucoma patients, in comparison with healthy controls (average value: 90.5 ± 13.02 and 74.72 ± 11.35, for glaucoma and healthy subjects, respectively; p < 0.01). Significant correlations between the average number of HRS and visual field mean deviation (MD, p = 0.01) and pattern standard deviation (PSD, p < 0.01) were found. Conclusions: OCT images from glaucoma patients showed a higher number of HRS when compared with healthy controls. As HRS have been hypothesized to be a sign of neuroinflammation, these results may support the role of neuroinflammation in glaucoma etiopathogenesis.
Highlights
Glaucoma is a neurodegenerative disease consisting of a non-uniform group of ocular disorders characterized by a number of clinical features including visual field (VF) defects, retinal ganglion cell (RGC) death and progressive degeneration of the optic nerve
An increased number of hyper-reflective retinal spots (HRS) was first described in optical coherence tomography (OCT) scans from patients affected with age-related macular degeneration (AMD) by Coscas et al, who suggested
The same group of authors found a reduction of the HRS numerosity in OCT scans from AMD patients treated with intravitreal injections of anti-vascular endothelial growth factor, and identified the increase of HRS as the first relevant sign of disease re-activation at OCT [9]
Summary
Glaucoma is a neurodegenerative disease consisting of a non-uniform group of ocular disorders characterized by a number of clinical features including visual field (VF) defects, retinal ganglion cell (RGC) death and progressive degeneration of the optic nerve. This optic neuropathy represents a complex, multifactorial disease, in which several molecular pathways are involved. Growing evidence suggests that the interaction of RGCs and glial cells, including microglial cells, retinal astrocytes and Muller cells, is critically important for the process of glaucomatous neurodegeneration [1,2].
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