A comparison of glyburide and insulin treatment in gestational diabetes mellitus on infant birth weight and adiposity

Abstract

162 163 LIKELIHOOD OF DIABETES RECURRENCE IN WOMEN WITH MILD GESTATIONAL DIABETES (GDM) HEATHER J. HOLMES, BRIAN M. CASEY, JULIE Y. LO, DONALD D. MCINTIRE, KENNETH J. LEVENO, University of Texas Southwestern Medical Center at Dallas, Obstetrics and Gynecology, Dallas, TX OBJECTIVE: To evaluate the likelihood of recurrence of diabetes during subsequent pregnancies in women with class A1 GDM. STUDY DESIGN: This is a retrospective cohort analysis of nulliparous women diagnosed with GDM and delivered of a singleton infant between January 1991 and June 2003. Pregnant women with a 50-gm oral glucose screen of $140 mg/dL were tested with a 100-gm glucose tolerance test. Women who had two or more abnormal values using NDDG criteria were diagnosed with GDM and those with fasting values less than 105 mg/dL were diagnosed with class A1 GDM and treated with diet alone. Women with a prior history of GDM were routinely screened at initial presentation for prenatal care during subsequent pregnancies. Those womenwith diabetes in a subsequent pregnancy were compared to those who did not have recurrent diabetes. The probability of recurrence of diabetes was calculated using maternal age at first pregnancy, interpregnancy interval, and body mass index (BMI) during the subsequent pregnancy. RESULTS: During the study period, 344 women were identified with class A1 GDM during their first pregnancy and had an additional delivery in our database. 137 (40%) were identified with diabetes during their subsequent pregnancy. Depicted in the graph below is the probability of diabetes recurrence according to age and interpregnancy interval for women with a BMI of 30. Similar analyses were performed for women with a BMI of 25 and 35. CONCLUSION: (1) The probability of diabetes recurrence in pregnant women with a history of GDM is related to age, interpregnancy interval, and BMI. (2) These probability assessments can be used to counsel women with a history of GDM. December 2003 Am J Obstet Gynecol S108 SMFM Abstracts